The Fat Hormone: How Effective are You at Burning Belly Fat?

Leptin, a recently discovered hormone, regulates body weight by suppressing food intake and/or increasing energy expenditure.

Leptin is a very powerful and influential hormone produced by fat cells.

Science has discovered that leptin is the most powerful metabolic regulator that tells your brain whether you should be hungry, eat and make more fat.

Basically, leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it.

In a perfect world, as you gain weight, you secrete more leptin from your fat cells. This in turn tells your brain you have enough stored fat so it reduces your appetite sending messages to help you burn fat.

But there is a problem!

Unfortunately many people have something called “leptin resistance”. This means that no matter how much leptin you create from your fat cells, the brain doesn’t see it.  This leads to a cascade of your brain thinking you are starving ======> you burn less calories ====>your appetite goes into overdrive and finally every bit of food you eat gets stored on your belly!

Until you address leptin resistance, you’re not going to lose weight!

Optimal Leptin Levels

Your goal is to keep your leptins below 12, however, not too low. Researchers have discovered that leptins too far to the low side has been associated with dementia or Alzheimer’s.

A leptin above 12 is not considered healthy.

Leptin levels can now be measured with a simple blood test. Levels above 12 are linked to weight gain, accelerated aging, increased risk of infertility, diabetes and heart attack.  In addition, high leptin levels are associated with belly fat and numerous cancers

Leptin rises if you don’t sleep well, and if you have any kind of perceived stress.

Thyroid Connection

If you are having difficulty losing weight, I recommend you get your leptin checked. Remember you want it under 12.  From a thyroid perspective, if your leptin is above 12 you will commonly see low T3 (the most metabolically active thyroid hormone) and elevated reverse T3. This is not good for those trying to lose weight. The thyroid medication Synthroid (Levothyroxine) is aT4 medication and should be used with some level of caution when high leptin levels are seen. The take away from this thyroid connection is the fact that reverse T3 means T4 is not being effectively converted into the metabolic workhorse hormone, T3.

The Solution:

You become leptin resistant by eating the typical American diet full of sugar, refined grains, and processed foods. The solution is to eat a diet that emphasizes good fats and avoids blood sugar spikes. Basically a diet that emphasize healthy fats, lean meats and vegetables, and restricts sugar and grains.

For a full thyroid/leptin work-up, I recommend a comprehensive blood analysis that includes both a full, NOT partial, Thyroid panel & the Leptin marker.







Compliments of Functional Medicine University.

Breakthrough Hashimoto’s Diet Coming Soon! And It’s Not The Paleo Diet?


Although many people with Hashimoto’s find great success following a gluten-free, autoimmune, or Paleo diet, it’s clear these diets do not go the distance in managing Hashimoto’s for everyone. Dr. Datis Kharrazian recently worked with world-renowned immunologist Dr. Aristo Vojdani conducting research in complex cross-reactive mechanisms. They evaluated molecular mimicry between the entire thyroid axis and more than 200 foods and numerous common chemicals – in other words, They looked at how specific foods or chemicals triggered immune reactions to specific areas of the thyroid.

Molecular mimicry means the antibody of a food or chemical is so similar in structure to that of a body tissue that the immune system confuses the two. For example, processed soy protein has a similar amino acid sequence to that of thyroglobulin, a protein in the thyroid gland used to produce thyroid hormone. If one has an immune reaction to processed soy protein, then the soy antibodies can bind to thyroglobulin due to molecular mimicry. As a result, the immune system attacks both the processed soy protein AND the thyroid tissue in an autoimmune process.

In their study they used a laboratory method called ELISA to look for cross-reactivity between human antibodies for the entire thyroid axis (TSH, TPO, thyroglobulin, 5’ deiodinase, T3, and T4) and more than 200 purified dietary proteins and over a dozen chemicals bound to human protein.

Dr. Vojdani and Dr. Kharrazian found that more than 30 foods, many of which are on the Paleo diet, cross-react — or induce molecular mimicry — with various parts of the thyroid axis. The findings of this research will lead to dietary guidelines that are more specific then the general Paleo or autoimmune diet.

At this time, the data is being formulated into a paper that will be submitted to a scientific journal for peer-review. They cannot disclose the outcomes until there is an independent evaluation of the research process. As soon as the study is validated by independent researchers and published they will post the dietary guidelines to further support their Hashimoto’s readers. They are confident this research could change everything!

Original Blog By Dr. Kharrazian, DHSc, DC, MS, MNeuroSci @